Author

Lisa Marie Ramirez

German Center for Neurodegenerative DiseasesORCID 0000-0002-4072-325XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 2 Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Assay:proteomics· 2 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

Markus ZweckstetteriD· 2 shared Ali RezaeiiD· 1 shared Anusha B. GopalaniD· 1 shared Davide Di LorenzoiD· 1 shared Dieter EdbaueriD· 1 shared Dorothee DormanniD· 1 shared Federico UlianaiD· 1 shared Francesca SimonettiiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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Focal author (center)Selected co-authorORCID co-authorUnlinked name

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2 shared papersPharmacology & Toxicology

Markus ZweckstetterORCID

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2 papers

Recent·Most cited

Synthetic chaperone based on Hsp90-Tau interaction inhibits pathological Tau aggregation and rescues physiological Tau-Microtubule interaction

Davide Di Lorenzo, Nicolò Bisi, Julia Kaffy, Lisa Marie Ramirez, Markus Zweckstetter, Olivier Lequin, Irene Garfagnini, Jinghui Luo, Yvonne Hannappel, Inga Ennen, Veronica Isabel Dodero, Norbert Sewald, Maria Luisa Gelmi, Nicolò Tonali, Roland Brandt, Sandrine Ongeri

This paper designs a synthetic peptide mimicking Hsp90-Tau interaction to inhibit Tau aggregation and restore its microtubule binding, showing efficacy in vitro and in cells.

Nature Communications · Oct 1, 2025Peer-reviewedPharmacology & Toxicology

Direct binding of TDP-43 and Tau drives their co-condensation, but suppresses Tau fibril formation and seeding

Francesca Simonetti, Weijia Zhong, Saskia Hutten, Federico Uliana, Martina Schifferer, Ali Rezaei, Lisa Marie Ramirez, Janine Hochmair, Rithika Sankar, Anusha B. Gopalan, Fridolin Kielisch, Henrick Riemenschneider, Viktoria Ruf, Mikael Simons, Markus Zweckstetter, , Dorothee Dormann

This study shows that TDP-43 and Tau directly interact, promoting co-condensation but reducing Tau fibril formation and seeding.

bioRxiv · Jul 7, 2025 · PreprintBiochemistry