Giuliano Scarcelli

This study shows that pro-inflammatory polarization of macrophages increases nuclear stiffness despite reduced lamin A/C levels, suggesting chromatin changes drive nuclear mechanics.

This study identifies the A-type lamin rod domain as the key determinant of nuclear deformability, revealing its unique role in resisting large mechanical forces on the nucleus.

This paper shows that disrupting Fuz in mouse embryos causes hypoplastic hindbrain development and reduced cranial nerve ganglia due to defective cilia formation and impaired Sonic Hedgehog signaling.

The paper investigates how reduced tissue stiffness in Mthfd1l mutant mouse embryos impairs neural tube closure and shows that formate supplementation can restore stiffness and morphology.