Jacob Odell

This study shows that pro-inflammatory polarization of macrophages increases nuclear stiffness despite reduced lamin A/C levels, suggesting chromatin changes drive nuclear mechanics.

This study shows that A-type and B-type lamins have opposing roles in LBR localization and dynamics, with lamin A displacing LBR from the nuclear envelope while lamin B1/B2 tether it.

This study identifies two independent binding sites on lamin A/C that anchor emerin at the inner nuclear membrane, revealing a revised model for emerin retention.

This study identifies key cellular programs and pathways driving metastatic organotropism in small cell lung cancer using preclinical models and multiomic profiling.

This study identifies the A-type lamin rod domain as the key determinant of nuclear deformability, revealing its unique role in resisting large mechanical forces on the nucleus.

This study shows that N-terminal tags on Lamin A affect its nuclear structural support functions but not all its roles in mammalian cells.