Author

Adam W. Clemens

Washington University in St. LouisORCID 0000-0002-1780-9979Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2 Genomics· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 3 Approach:statistical model· 3 Assay:DNA methylation· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

Harrison W. GabeliD· 3 shared Dennis Y. WuiD· 2 shared J. Russell Moore· 2 shared Nicole HamagamiiD· 2 shared Sabin A. NettlesiD· 2 shared Aidan Li· 1 shared Alaina UrmaniD· 1 shared Cheryl A. HilliD· 1 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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3 shared papersNeuroscience

Harrison W. GabelORCID

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3 papers

Recent·Most cited

Non-CG DNA methylation and MeCP2 stabilize repeated tuning of long genes that distinguish closely related neuron types

J. Russell Moore, Mati T. Nemera, Rinaldo D. D’Souza, Nicole Hamagami, Adam W. Clemens, Diana C. Beard, Alaina Urman, Victoria Rodriguez Mendoza, Harrison W. Gabel

The paper shows that non-CG DNA methylation and MeCP2 regulate long genes to maintain neuron type-specific gene programs at high resolution.

bioRxiv · Jan 30, 2024 · PreprintNeuroscience

NSD1 deposits histone H3 lysine 36 dimethylation to pattern non-CG DNA methylation in neurons

Nicole Hamagami, Dennis Y. Wu, Adam W. Clemens, Sabin A. Nettles, Aidan Li, Harrison W. Gabel

The paper shows NSD1 deposits H3K36me2 to pattern non-CG DNA methylation in neurons, linking this to neurodevelopmental disorders.

Molecular Cell · Apr 24, 2023Peer-reviewedGenomics

DNMT3A haploinsufficiency results in behavioral deficits and global epigenomic dysregulation shared across neurodevelopmental disorders

Diana L. Christian, Dennis Y. Wu, Jenna R. Martin, J. Russell Moore, Yiran R. Liu, Adam W. Clemens, Sabin A. Nettles, Nicole M. Kirkland, Thomas Papouin, Cheryl A. Hill, David F. Wozniak, Joseph D. Dougherty, Harrison W. Gabel

This study shows that DNMT3A mutations cause behavioral and epigenomic changes in mice, similar to human neurodevelopmental disorders, by disrupting non-CG DNA methylation.

Cell Reports · Nov 1, 2020Peer-reviewedNeuroscience