Author

Dennis Y. Wu

Washington University in St. LouisORCID 0000-0002-3808-6271Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2 Genomics· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 3 Assay:DNA methylation· 3 Approach:experimental assay· 3 Research Focus:gene regulatory network inference· 3 Organism:mouse· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Approach:statistical model· 2

Frequent Co-Authors

Harrison W. GabeliD· 3 shared Adam W. ClemensiD· 2 shared Cheryl A. HilliD· 2 shared Jenna R. Martin· 2 shared Joseph D. DoughertyiD· 2 shared Nicole HamagamiiD· 2 shared Sabin A. NettlesiD· 2 shared Thomas PapouiniD· 2 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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3 shared papersNeuroscience

Harrison W. GabelORCID

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3 papers

Recent·Most cited

NeuroscienceCell ReportsPeer-reviewedNov 1, 2023

Distinct disease mutations in DNMT3A result in a spectrum of behavioral, epigenetic, and transcriptional deficits

Diana C. Beard, Xiyun Zhang, Dennis Y. Wu…·Harrison W. Gabel

This study examines how different DNMT3A mutations cause varied behavioral, epigenetic, and transcriptional issues in neurodevelopmental disorders.

29 citationstop 3%

mouseDNA methylation

𝕏 PostBluesky

GenomicsMolecular CellPeer-reviewedApr 24, 2023

NSD1 deposits histone H3 lysine 36 dimethylation to pattern non-CG DNA methylation in neurons

Nicole Hamagami, Dennis Y. Wu, Adam W. Clemens…·Harrison W. Gabel

The paper shows NSD1 deposits H3K36me2 to pattern non-CG DNA methylation in neurons, linking this to neurodevelopmental disorders.

44 citationstop 4%

mouseDNA methylation

𝕏 PostBluesky

NeuroscienceCell ReportsPeer-reviewedNov 1, 2020

DNMT3A haploinsufficiency results in behavioral deficits and global epigenomic dysregulation shared across neurodevelopmental disorders

Diana L. Christian, Dennis Y. Wu, Jenna R. Martin…·Harrison W. Gabel

This study shows that DNMT3A mutations cause behavioral and epigenomic changes in mice, similar to human neurodevelopmental disorders, by disrupting non-CG DNA methylation.

78 citationstop 4%

mouseDNA methylation

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