Luuk Loeff

The paper shows that forked DNA activates a helicase-nuclease immune complex in type III Druantia through enzymatic processing, enabling phage defense without host toxicity.

This study identifies bacterial Schlafen nucleases as antiviral effectors that target phage infection by cleaving tRNA and inducing abortive infection.

This study uses cryo-EM to elucidate the mechanism of plasmid elimination by the DdmDE defense system in Vibrio cholerae.