David William Adams

Synthetically designed anti-defense proteins overcome barriers to bacterial transformation and phage infection

The paper designs synthetic proteins that inhibit bacterial defense systems, enabling phage infection and plasmid transformation in otherwise resistant strains.

Structure and Activation Mechanism of a Lamassu Phage Defence System

The paper presents structures of a Lamassu defence system from Salmonella enterica, revealing how LmuA nuclease effector is activated by oligomerization and DNA cleavage.

Diverse phage defence systems define West African South American pandemic Vibrio cholerae

The paper identifies two anti-phage defence systems in the WASA lineage of V. cholerae that may contribute to its epidemic success.

Vibrio cholerae pathogenicity island 2 encodes two distinct types of restriction systems

This study identifies a novel restriction system within Vibrio cholerae pathogenicity island 2 that targets non-methylated plasmids and has anti-phage activity against Tevenvirinae phages.

Molecular mechanism of plasmid elimination by the DdmDE defense system

This study uses cryo-EM to elucidate the mechanism of plasmid elimination by the DdmDE defense system in Vibrio cholerae.