Melanie Blokesch

The paper designs synthetic proteins that inhibit bacterial defense systems, enabling phage infection and plasmid transformation in otherwise resistant strains.

The paper introduces two tools to recover integron cassettes from bacterial genomes, identifying new phage-defense systems.

The paper presents structures of a Lamassu defence system from Salmonella enterica, revealing how LmuA nuclease effector is activated by oligomerization and DNA cleavage.

The paper identifies two anti-phage defence systems in the WASA lineage of V. cholerae that may contribute to its epidemic success.

This study analyzes MGEs and defense systems in 46 V. cholerae strains to explore their diversity and evolutionary dynamics.

This study shows that capsular polysaccharide in Acinetobacter baumannii reduces both its own and rival bacteria's T6SS efficacy, with increased CPS production exacerbating self-T6SS impairment.

This study identifies a novel restriction system within Vibrio cholerae pathogenicity island 2 that targets non-methylated plasmids and has anti-phage activity against Tevenvirinae phages.

This study uses cryo-EM to elucidate the mechanism of plasmid elimination by the DdmDE defense system in Vibrio cholerae.