A double-negative prostate cancer subtype is vulnerable to SWI/SNF-targeting degrader molecules
Phillip Thienger, Irene Paassen, Xiaosai Yao, Philip D. Rubin, Marika Lehner, Nicholas Lillis, Andrej Benjak, Sagar R Shah, Alden King-Yung Leung, Simone de Brot, Alina Naveed, Bence Dániel, Minyi Shi, Julien Tremblay, Joanna Triscott, , Mark A. Rubin
This study identifies a SWI/SNF-targeting therapy effective against a double-negative prostate cancer subtype, showing it reduces viability in both AR-dependent and WNT-dependent models.
Cancer Research · Jan 14, 2026Peer-reviewedCancer Biology