Author

John D. Helmann

Cornell UniversityORCID 0000-0002-3832-3249Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:bacteria (other)· 4 Research Focus:chromatin & epigenetic regulation· 2 Research Focus:host-pathogen & immune response· 2 Approach:biophysical modeling· 1 Research Focus:cell signaling & trafficking· 1 Organism:human· 1 Research Focus:metabolism & bioenergetics· 1

Frequent Co-Authors

Gerald J. BarnesiD· 2 shared Yesha S. PateliD· 2 shared Amelie AndreasiD· 1 shared Ankita J. SachlaiD· 1 shared Arthur GlasfeldiD· 1 shared Daniel ZhitnitskyiD· 1 shared Dia Zheng· 1 shared Eric J. RubiniD· 1 shared

Activity by Year

2025-2026 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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2 shared papersMicrobiology

Gerald J. BarnesORCID

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Physiological Roles of Carbonic Anhydrases and an MpsAB-like Bicarbonate Transporter in Bacillus subtilis

Gerald J. Barnes, John D. Helmann

This study shows that Bacillus subtilis requires bicarbonate for anabolic processes and that CO2 can be used as a substrate when endogenous CO2 production is increased.

bioRxiv · Sep 8, 2026 · PreprintMicrobiology

The Bacillus subtilis class A penicillin-binding protein 4 (PBP4) requires an accessory protein RpdA

Ruoqi Huang, Yesha S. Patel, John D. Helmann

This study identifies RpdA as an accessory protein required for PBP4 localization and activity in Bacillus subtilis, contributing to antibiotic resistance and PG synthesis.

bioRxiv · Dec 22, 2025 · PreprintMicrobiology

RNA polymerase-mediated regulation of intrinsic antibiotic resistance and bacterial cell division

Vijay Soni, Junhao Zhu, Yesha S. Patel, John D. Helmann, Eric J. Rubin, Kyu Young Rhee

This study identifies a novel mechanism by which rifampin shortens TB treatment by inhibiting Mtb RNA polymerase, leading to cell division arrest and reduced antibiotic resistance.

bioRxiv · Jul 20, 2025 · PreprintMicrobiology

Copper acquisition in Bacillus subtilis involves Cu(II) exchange between YcnI and YcnJ

Yuri Rafael de Oliveira Silva, Grayson Barnes, Dia Zheng, Daniel Zhitnitsky, Samuel J. Geathers, Stephen C. Peters, Veronika A. Szalai, John D. Helmann, Oriana S. Fisher

This study identifies a Cu(II) exchange mechanism between YcnI and YcnJ in B. subtilis, showing their roles in copper acquisition and regulation under copper limitation.

Journal of Biological Chemistry · Jul 15, 2025Peer-reviewedBiochemistry

Structural basis for transcription activation through cooperative recruitment of MntR

Haoyuan Shi, Yu Fu, Vilmante Kodyte, Amelie Andreas, Ankita J. Sachla, Keikilani Miller, Ritu Shrestha, John D. Helmann, Arthur Glasfeld, Shivani Ahuja

This study determines the structural basis of MntR-mediated gene activation through cooperative DNA binding using cryo-EM and complementary assays.

Nature Communications · Mar 5, 2025Peer-reviewedBiochemistry