Juan R. Perilla

The paper determines the structure of HIV-1 capsid lattice bound to MxB N-terminal fragment, revealing an alpha-helix stabilizes binding at the trimer interface.

This study shows that CypA binding to HIV-1 capsids affects their mechanical properties, with higher stoichiometry increasing brittleness and reducing deformability.

The paper introduces a geometric criterion to quantify deviations in HIV-1 capsid structure from idealized models and links these deviations to biophysical properties and function.

This study investigates how Lenacapavir disrupts HIV-1 assembly and maturation, revealing a 'premature' lattice formation that prevents infectious virus production.

This study identifies a hybrid Gag lattice as an intermediate in HIV-1 maturation, showing it is stabilized by IP6 and essential for infectivity.

This study determines high-resolution structures of immature HIV-1 particles with inhibitors BVM and LEN bound using cryo-EM, revealing their distinct binding mechanisms and effects on Gag lattice architecture.

This study uses cryo-ET to reveal the structure and dynamics of native pyrenoid Rubisco in Chlamydomonas reinhardtii, showing variations in active site and dimer interface and associations with binding proteins.

This study shows that an ordered mature MA lattice is not required for HIV-1 infectivity, as a triple mutant lacking this structure remains infectious.

This paper identifies a mutation, G225R, that restores capsid formation and infectivity to HIV-1 mutants deficient in IP6 packaging by stabilizing the capsid structure in low-IP6 conditions.

This paper identifies the mechanism of resistance to the HIV-1 integrase inhibitor pirmitegravir and develops a more potent analog to overcome this resistance.