Author

Romualdo Barroso‐Sousa

Dana-Farber Cancer InstituteORCID 0000-0002-1825-9876Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genomics· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 3 Organism:human· 3 Approach:statistical model· 2 Research Focus:variant calling· 2 Assay:whole-exome sequencing· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

Sara M. TolaneyiD· 3 shared Eric P. WineriD· 2 shared NU LiniD· 2 shared Adam NelsoniD· 1 shared Adrienne Gropper WaksiD· 1 shared Alinés Lebrón-TorresiD· 1 shared Ana Christina Garrido-CastroiD· 1 shared Andrew D. CherniackiD· 1 shared

Activity by Year

2020-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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3 shared papersGenomics

Sara M. TolaneyORCID

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3 papers

Recent·Most cited

APOE Tumor-Associated Macrophages and CD4-DOCK4 T Cells Reveal Distinct Microenvironmental Features in HER2-Low and HER2-0 Hormone Receptor-Positive Breast Cancer

Carlos Wagner S Wanderley, Daniel E. Michaud, Kenichi Shimada, Adam Nelson, Jingxin Fu, Stuart J. Schnitt, Sara M. Tolaney, Elizabeth Ann Mittendorf, Romualdo Barroso‐Sousa, Adrienne Gropper Waks, Paolo Tarantino, Jennifer L. Guerriero

The paper identifies distinct immune and stromal features in HR+ HER2-low and HER2-0 breast cancers using molecular and multiplexed imaging.

bioRxiv · Sep 4, 2025 · PreprintCancer Biology

Clinicogenomic characterization of inflammatory breast cancer

Nolan Priedigkeit, Beth T. Harrison, Robert E. Shue, Melissa E. Hughes, Yvonne Y. Li, Alinés Lebrón-Torres, Gregory John Kirkner, Liam Flinn Spurr, Marie Claire Remolano, Sarah Strauss, Janet L. Files, Anne-Marie Feeney, Libby Grant, Ayesha Mohammed-Abreu, Ana Christina Garrido-Castro, , Filipa C. Lynce

This study analyzes genomic alterations in a large IBC cohort, finding high TP53 mutation frequency and NOTCH pathway enrichment, but no major genomic differences compared to non-IBC cases.

Clinical Cancer Research · May 16, 2025Peer-reviewedGenomics

Prevalence and mutational determinants of high tumor mutation burden in breast cancer

Romualdo Barroso‐Sousa, Esha Jain, Ofir Cohen, D. Kim, Jorge E. Buendia-Buendia, Eric P. Winer, NU Lin, Sara M. Tolaney, Nikhil Wagle

This study finds that 5% of breast cancers have high tumor mutation burden, more common in metastatic tumors, with APOBEC activity as the most common mutational process and potential benefit from PD-1 inhibitors.

Annals of Oncology · Jan 9, 2020Peer-reviewedGenomics