John Gallacher

Autoencoder-based phenotyping of ophthalmic images highlights genetic loci influencing retinal morphology and provides epidemiologically informative biomarkers.

The paper uses an autoencoder to derive retinal phenotypes from OCT images, identifies 118 genetic loci, and shows their relevance to retinal morphology and disease prediction.

Semantic harmonization of Alzheimer's disease datasets using AD-Mapper

This paper introduces AD-Mapper, a tool for semantic harmonization of Alzheimer's disease datasets, which outperforms a string-matching baseline.

Adapting the Eysenck Personality Questionnaire-Revised Neuroticism scale for use in epidemiologic studies: A psychometric evaluation using item response theory in the UK Biobank

The paper evaluates the psychometric properties of the EPQ-RN neuroticism scale using IRT in the UK Biobank, identifying a 7-item scale as most informative for measuring neuroticism.

The long arm of childhood socioeconomic deprivation on mid- to later-life cognitive trajectories : A cross-cohort analysis

This study examines how childhood socioeconomic deprivation affects cognitive trajectories across mid- to later-life using three cohorts, finding associations with lower trajectory classes.

Associations of adverse lifetime experiences with brain structure in 7003 UK Biobank participants

This study examines the link between childhood and adult adversity and brain structure in 7003 UK Biobank participants, finding associations between childhood adversity and reduced grey matter in specific brain regions.

The Dementias Platform UK (DPUK) Data Portal

The DPUK Data Portal provides secure access to cohort data for dementia research, supporting multi-modal analyses and collaborations across multiple institutions.

Sex differences in interrelationships between arterial stiffness, carotid intima-media thickness, white matter hyperintensities, depression and cognition: A UK Biobank study