Jackson A. Hoffman

The paper shows that hormone response magnitude in mammary organoids and ER+ cancer cells varies independently of receptor abundance and follows distinct activation dynamics.

The paper shows that transcription initiation is not required for histone acetylation and H2AZ incorporation at TSSs but limits their maintenance.

This study shows BRG1 is essential for establishing the chromatin landscape in neural progenitor cells, ensuring proper expression of neuroectodermal transcription factors and preventing premature differentiation.