Susan A. Farr

Cannabidiol improves learning and memory deficits and alleviates anxiety in 12-month-old SAMP8 Mice

This study shows that chronic CBD administration improves learning and memory and reduces anxiety in aged SAMP8 mice, with potential therapeutic implications for age-related cognitive decline.

Biochemical, biomarker, and behavioral characterization of the GrnR493X mouse model of frontotemporal dementia

This study characterizes the GrnR493X mouse model of frontotemporal dementia, finding similar phenotypes to Grn knockout models but with differences in biomarker levels in heterozygous mice.

Antisense oligonucleotides targeting the miR-29b binding site in the GRN mRNA increase progranulin translation

This study shows that antisense oligonucleotides can increase progranulin protein levels by blocking miR-29b binding in GRN mRNA, offering a potential therapy for FTD.

A dual MTOR/NAD+ acting gerotherapy

This paper identifies BIOIO-1001 as a dual mTOR/NAD+ acting gerotherapy that reduces metabolic derangements, inflammation, and fibrosis in NASH and ALS models.

Adropin confers neuroprotection and promotes functional recovery from ischemic stroke

This study shows adropin protects against ischemic stroke by maintaining BBB integrity and reducing neuroinflammation, improving functional recovery in mice.