Autism-associated oxysterol regulates GABAergic neurogenesis and subtype fates
Maria Cruz-Santos, Ethan Kidd, Zongze Li, Daniel Cabezas de la Fuente, Sara Davies, Ngoc‐Nga Vinh, Marija Fjodorova, Meng Li
The paper shows that 24S,25-epoxysterol, an oxysterol linked to neurodevelopmental disorders, promotes neurogenesis and disrupts GABAergic neuronal subtype composition through the liver X receptor pathway.
bioRxiv · Jul 1, 2025 · PreprintDevelopmental Biology