Vorasuk Shotelersuk

The paper shows that YEATS2 regulates calcium homeostasis in dopaminergic neurons, and its disruption leads to neuronal loss and behavioral deficits, which can be rescued by inhibiting Orai channels.

This study performs a multi-ancestral GWAS of DSM-defined nicotine dependence, finding genetic correlations with other substance use disorders and health traits, and identifying a strong general addiction liability factor.

The paper estimates carrier frequencies of pathogenic variants in 113 ACMG-recommended genes using exome sequencing data from 1,642 Thai individuals, finding high carrier rates for several disorders.

The paper identifies a homozygous KIF6 mutation in a child with neurocranial defects and intellectual disability, showing its role in ependymal cell cilia maintenance and neuro-cranial development through mouse and zebrafish models.