Khyati Dalal

Widespread low-affinity motifs enhance chromatin accessibility and regulatory potential in mESCs

The paper maps and interprets low-affinity transcription factor motifs in mESCs, showing they enhance chromatin accessibility and regulatory potential through cooperative interactions.

Interpretable deep learning reveals the sequence rules of Hippo signaling

The paper uses interpretable deep learning to identify sequence rules governing Hippo signaling in mouse trophoblast stem cells, revealing how transcription factors influence enhancer activity.

Base-resolution models of transcription factor binding reveal soft motif syntax

The paper introduces BPNet, a deep learning model that predicts base-resolution ChIP-nexus binding profiles of TFs and identifies soft syntax rules for cooperative TF binding.

A long-range chromatin interaction regulates SATB homeobox 1 gene expression in trophoblast stem cells

The paper identifies a long-range chromatin interaction that regulates Satb1 expression in trophoblast stem cells through ELF5 and SATB protein interactions.