Robin Fropf

Spatially resolved whole transcriptome profiling in human and mouse tissue using Digital Spatial Profiling

Multiplexed in situ hybridization pools against every protein-coding gene let Digital Spatial Profiling read whole transcriptomes from regions of ~10-500 cells in human and mouse tissue.

Transcriptome-wide spatial RNA profiling maps the cellular architecture of the developing human neocortex

This paper introduces a new spatial transcriptomic technology, WTA, and applies it to map the cellular architecture of the developing human neocortex, showing spatial enrichment of autism-related genes.

A single-cell and spatial atlas of autopsy tissues reveals pathology and cellular targets of SARS-CoV-2

This study creates a single-cell and spatial atlas of autopsy tissues from COVID-19 patients, revealing altered cellular responses and potential therapeutic targets.

Base-resolution models of transcription factor binding reveal soft motif syntax

The paper introduces BPNet, a deep learning model that predicts base-resolution ChIP-nexus binding profiles of TFs and identifies soft syntax rules for cooperative TF binding.

Single-nucleus and spatial transcriptomics of archival pancreatic cancer reveals multi-compartment reprogramming after neoadjuvant treatment

This study uses single-nucleus and spatial transcriptomics to analyze pancreatic cancer before and after neoadjuvant treatment, revealing changes in cell states and immune infiltration that may inform therapy.