BiophysicsbioRxivPreprint
Tandem association of CLOCK:BMAL1 complexes on DNA enables recruitment of CBP/p300 through multivalent interactions
Diksha Sharma, Lisa Stoos, Megan R Torgrimson…·Carrie L. Partch
The paper shows that tandem E-boxes enable CLOCK:BMAL1 to bind more sites on nucleosomes, promoting multivalent interactions with CBP/p300 to drive gene expression.
2 citations