Tandem association of CLOCK:BMAL1 complexes on DNA enables recruitment of CBP/p300 through multivalent interactions
Diksha Sharma, Lisa Stoos, Megan R Torgrimson, Priya Crosby, Kyle M. Franks, Nicole C. Parsley, Miles W. Membreño, Georg Kempf, Lukas Kater, Chelsea L. Gustafson, Hsiau‐Wei Lee, Seth M. Rubin, Alicia K. Michael, Nicolas H. Thomä, Carrie L. Partch
The paper shows that tandem E-boxes enable CLOCK:BMAL1 to bind more sites on nucleosomes, promoting multivalent interactions with CBP/p300 to drive gene expression.
bioRxiv · Sep 4, 2025 · PreprintBiophysics