Author

Hsiau‐Wei Lee

University of California, Santa CruzORCID 0000-0002-6060-6341Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cell signaling & trafficking· 1 Assay:ChIP-seq· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:DNA methylation· 1 Research Focus:transcription & RNA processing· 1 Approach:wet-lab / biochemical assay· 1

Frequent Co-Authors

Carrie L. PartchiD· 2 shared Alicia K. MichaeliD· 1 shared Carlos A. Amezcua· 1 shared Chelsea L. Gustafson· 1 shared Denize C. FavaroiD· 1 shared Diksha SharmaiD· 1 shared Diksha SharmaiD· 1 shared Ethen West· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersBiochemistry

Carrie L. PartchORCID

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2 papers

Recent·Most cited

BiochemistrybioRxivPreprintOct 22, 2026

Small Molecule Regulation of CLOCK:BMAL1 DNA Binding Activity

Diksha Sharma, Soumendu Boral, Ethen West…·Carrie L. Partch

This study identifies small molecules that bind to the PAS-A domain of CLOCK and NPAS2, stabilizing the domain and reducing DNA binding affinity of CLOCK:BMAL1.

1 citation

experimental assay

𝕏 PostBluesky

BiophysicsbioRxivPreprintSep 4, 2025

Tandem association of CLOCK:BMAL1 complexes on DNA enables recruitment of CBP/p300 through multivalent interactions

Diksha Sharma, Lisa Stoos, Megan R Torgrimson…·Carrie L. Partch

The paper shows that tandem E-boxes enable CLOCK:BMAL1 to bind more sites on nucleosomes, promoting multivalent interactions with CBP/p300 to drive gene expression.

2 citations

DNA methylationChIP-seq

𝕏 PostBluesky