GenomicsMolecular CellPeer-reviewed
Unraveling intratumoral heterogeneity through high-sensitivity single-cell mutational analysis and parallel RNA-sequencing
Alba Rodríguez-Meira, Gemma Buck, Sally‐Ann Clark…·Adam J. Mead
This study introduces TARGET-seq, a method that simultaneously detects mutations and performs RNA-sequencing in single cells, revealing transcriptional and genetic tumor heterogeneity in myeloproliferative neoplasm cells.