Unraveling intratumoral heterogeneity through high-sensitivity single-cell mutational analysis and parallel RNA-sequencing
Alba Rodríguez-Meira, Gemma Buck, Sally‐Ann Clark, Benjamin J. Povinelli, Verónica Alcolea, Eleni Louka, Simon J. McGowan, Angela D. Hamblin, Nikolaos Sousos, Nikolaos Barkas, Alice Giustacchini, Bethan Psaila, Sten Eirik W. Jacobsen, Supat Thongjuea, Adam J. Mead
This study introduces TARGET-seq, a method that simultaneously detects mutations and performs RNA-sequencing in single cells, revealing transcriptional and genetic tumor heterogeneity in myeloproliferative neoplasm cells.
Molecular Cell · Feb 11, 2019Peer-reviewedGenomics