Alice Giustacchini

This study identifies three leukaemia stem cell subtypes in paediatric AML and shows that combining CLEC12A and CD84 targets all subtypes while sparing healthy cells.

scINTILLA assesses cell-type annotation quality in single-cell datasets by combining supervised and unsupervised learning to identify label ambiguity and hidden heterogeneity.

The paper identifies HSP90 inhibitors as potential therapies for t(7;12)-AML by combining computational drug screening with in vitro experiments.

This study introduces TARGET-seq, a method that simultaneously detects mutations and performs RNA-sequencing in single cells, revealing transcriptional and genetic tumor heterogeneity in myeloproliferative neoplasm cells.