Eleni Louka

Genome editing for treatment of JAK2 V617F-driven myeloproliferative neoplasms

This study uses CRISPR-Cas genome editing to selectively inactivate JAK2 V617F mutations in patient cells, showing that heterozygous cells are not oncogene addicted while homozygous cells are eradicated, suggesting genome editing as a potential treatment for MPNs.

Unraveling intratumoral heterogeneity through high-sensitivity single-cell mutational analysis and parallel RNA-sequencing

This study introduces TARGET-seq, a method that simultaneously detects mutations and performs RNA-sequencing in single cells, revealing transcriptional and genetic tumor heterogeneity in myeloproliferative neoplasm cells.

Telomerecat: A Ploidy-Agnostic Method For Estimating Telomere Length From Whole Genome Sequencing Data

Telomerecat estimates telomere length from whole-genome sequencing data without requiring prior knowledge of ploidy, showing good performance and detecting expected patterns in various data types.