Graeme Milligan

Mechanism of GPR84 allosteric modulation at a helix 8-proximate site

This paper identifies a helix 8-proximate allosteric site in GPR84 and shows how it enables Gi-biased signalling through structural and dynamic mechanisms.

Steric control of signaling bias in the immunometabolic receptor GPR84

The paper identifies ligands with varying steric profiles that exhibit different β-arrestin recruitment capacities at GPR84, revealing a mechanism for controlling signaling bias.

NaBC1 boron transporter enables myoblast response to substrate rigidity via fibronectin-binding integrins

This study shows NaBC1, a boron transporter, enhances myoblast adhesion and tension in response to substrate rigidity via fibronectin-binding integrins.

Astrocytes expressing M4 muscarinic acetylcholine receptor regulate locomotion and survival in murine prion disease

The paper identifies a subpopulation of M4 mAChR-expressing astrocytes that regulate locomotion and have a detrimental effect in murine prion disease.

Diffusion and Oligomerization States of the Muscarinic M1 Receptor in Live Cells - The Impact of Ligands and Membrane Disruptors

This study uses single-molecule techniques to analyze the diffusion and oligomerization of M1R in live cells, showing ligands and membrane disruptors modulate these states.