Author

Amy E. Spens

Fred Hutch Cancer CenterORCID 0000-0002-1902-1309Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Developmental Biology· 1 Genetics· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Assay:ChIP-seq· 1 Assay:DNA methylation· 1 Organism:Drosophila· 1

Frequent Co-Authors

Amy E. CampbelliD· 1 shared Devon A. StorkiD· 1 shared Edward SukartoiD· 1 shared Erika Alden DeBenedictisiD· 1 shared Fatima R Martin· 1 shared Harley Greene· 1 shared Jonathan Liu· 1 shared Jordan E. MancusoiD· 1 shared

Activity by Year

2019-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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1 shared paperDevelopmental Biology

Amy E. CampbellORCID

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3 papers

Recent·Most cited

BioBloom, a method for barcoded saturation mutagenesis of an entire bacterial genome

Max G Schubert, Edward Sukarto, Fatima R Martin, Jordan E. Mancuso, Amy E. Spens, Tom Pedersen, Keren Isaev, Harley Greene, Nathan D. Hicks, Una Nattermann, Jonathan Liu, Devon A. Stork, Erika Alden DeBenedictis

BioBloom enables whole-genome barcoded saturation mutagenesis in E. coli, identifying beneficial mutations under salt and antibiotic selection with high coverage and efficiency.

bioRxiv · May 4, 2026 · PreprintMicrobiology

Human DUX4 and mouse Dux interact with STAT1 and broadly inhibit interferon-stimulated gene induction

Amy E. Spens, Nicholas A. Sutliff, Sean R. Bennett, Amy E. Campbell, Stephen J. Tapscott

This study shows DUX4 and mouse Dux interact with STAT1 and inhibit IFN-gamma-induced ISG expression by reducing STAT1 and Pol-II recruitment.

eLife · Apr 24, 2023Peer-reviewedDevelopmental Biology

Separate Polycomb Response Elements control chromatin state and activation of the vestigial gene

Kami Ahmad, Amy E. Spens

The paper shows that two PREs near the vestigial gene have distinct roles in gene activation and chromatin modification, challenging the idea that PREs solely repress gene expression.

PLoS Genetics · Aug 19, 2019Peer-reviewedGenetics