Author

Thomas H. Clarke

J. Craig Venter InstituteORCID 0000-0002-1916-1029Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 1 Genomics· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 2 Assay:whole-genome sequencing· 2 Organism:bacteria (other)· 1 Research Focus:cell type annotation· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Organism:mouse· 1 Research Focus:phylogenetics / evolution· 1

Frequent Co-Authors

Aric N. BrowniD· 2 shared Bridget S. MoricziD· 2 shared Caitlyn L. HolmesiD· 2 shared Derrick E. FoutsiD· 2 shared Elizabeth N. OttoseniD· 2 shared Geoffrey B. SeveriniD· 2 shared Harry L. T. MobleyiD· 2 shared Mark T. AndersoniD· 2 shared

Activity by Year

2017-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersMicrobiology

Aric N. BrownORCID

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3 papers

Recent·Most cited

MicrobiologyPLoS PathogensPeer-reviewedAug 23, 2024

Fitness Factor Genes Conserved within the Multi-species Core Genome of Gram-negative Enterobacterales Species Contribute to Bacteremia Pathogenesis

Harry L. T. Mobley, Mark T. Anderson, Bridget S. Moricz…·Michael A. Bachman

The paper identifies 18 conserved fitness genes in Enterobacterales species that contribute to bacteremia pathogenesis by testing mutants in a mouse model and finding attenuation in multiple organs.

10 citations

mouseexperimental assay

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BioinformaticsbioRxivPreprintJul 24, 2024

A novel method for integrating genomic and Tn-Seq data to identify common in vivo fitness mechanisms across multiple bacterial species

Derrick E. Fouts, Thomas H. Clarke, Aric N. Brown…·Harry L. T. Mobley

The paper integrates Tn-Seq fitness data with functional data to identify seven common fitness mechanisms across five Enterobacterales species, validating one gene's role in bacteremia and antibiotic resistance.

DOI 10.1101/2024.07.24.604993

bacteria (other)whole-genome sequencing

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GenomicsBMC BiologyPeer-reviewedJul 17, 2017

The house spider genome reveals an ancient whole-genome duplication during arachnid evolution

Evelyn E. Schwager, Prashant P. Sharma, Thomas H. Clarke…·Alistair P. McGregor

The paper analyzes the house spider genome to identify an ancient whole-genome duplication shared by spiders and scorpions, distinct from horseshoe crab duplications.

443 citationstop 1%

whole-genome sequencingstatistical model

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