Structural Basis of GPCR-G Protein Pre-coupling and Activation: Insights from CCR1-Gi Complex
Zhehua Shao, Yingjun Dong, Ruixin Jia, Qingya Shen, Bingpeng Yao, Xinheng He, Qingning Yuan, Dan-Dan Shen, Chunyou Mao, Chao Zhang, Zhihua Chen, H. Eric Xu, Songmin Ying, Yan Zhang, Wen Li
The paper solves the cryo-EM structure of CCR1-Gi complex in pre-coupled state, revealing molecular mechanism of GPCR-G protein activation and highlighting conserved pre-coupling in chemokine receptors.
bioRxiv · Nov 1, 2024 · PreprintBiophysics