Zhihua Chen

This study shows hypoxia alters T cell transcriptomes in melanoma, correlating with poor clinical outcomes in non-responders to immunotherapy.

The paper solves the cryo-EM structure of CCR1-Gi complex in pre-coupled state, revealing molecular mechanism of GPCR-G protein activation and highlighting conserved pre-coupling in chemokine receptors.

BERLIN reanalyzes single-cell RNAseq data to identify cell types and lineages, showing accurate results in acute myeloid leukemia and tumor-reactive lymphocytes.

This study combines genome-wide association data from four cancers to identify shared and novel genetic associations and pleiotropic effects.