BiophysicsbioRxivPreprint
Structural Basis of GPCR-G Protein Pre-coupling and Activation: Insights from CCR1-Gi Complex
Zhehua Shao, Yingjun Dong, Ruixin Jia…·Wen Li
The paper solves the cryo-EM structure of CCR1-Gi complex in pre-coupled state, revealing molecular mechanism of GPCR-G protein activation and highlighting conserved pre-coupling in chemokine receptors.