Zhehua Shao

This study shows that a buried LIR motif in PHB2 responds directly to temperature changes, affecting mitophagy and cardiac injury during heat stroke.

This study identifies NDUFA13-K7 acetylation as a sensor linking OXPHOS dysfunction to cristae remodelling and metabolic changes in heart failure.

The paper solves the cryo-EM structure of CCR1-Gi complex in pre-coupled state, revealing molecular mechanism of GPCR-G protein activation and highlighting conserved pre-coupling in chemokine receptors.