Molecular BiologybioRxivPreprint
Structural basis for the therapeutic advantage of dual and triple agonists at the human GIP, GLP-1 or GCG receptors
Fenghui Zhao, Qingtong Zhou, Zhaotong Cong…·Ming‐Wei Wang
This study determines cryo-EM structures of dual and triple agonists bound to GIPR, GLP-1R, and GCGR to elucidate their superior efficacy over monoagonists in glucose homeostasis.
5 citations