Author

Zhaotong Cong

Shanghai Medical College of Fudan University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Molecular Biology· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 4 Research Focus:cell type annotation· 1 Research Focus:protein structure prediction· 1 Assay:proteomics· 1

Frequent Co-Authors

Dehua YangiD· 4 shared Ming‐Wei WangiD· 4 shared Qingtong ZhouiD· 4 shared Yan ZhangiD· 4 shared Antao DaiiD· 3 shared H. Eric XuiD· 3 shared Li-Nan Chen· 3 shared Lihua ZhaoiD· 3 shared

Activity by Year

2021-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersMolecular Biology

Dehua YangORCID

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4 papers

Recent·Most cited

Structural basis of peptidomimetic agonism revealed by small molecule GLP-1R agonists Boc5 and WB4-24

Zhaotong Cong, Qingtong Zhou, Yang Li, Li-Nan Chen, Zi-Chen Zhang, Anyi Liang, Qing Liu, Xiaoyan Wu, Antao Dai, Tian Xia, Wei Wu, Yan Zhang, Dehua Yang, Ming‐Wei Wang

This paper reports cryo-EM structures of small molecule GLP-1R agonists Boc5 and WB4-24, revealing a novel binding pocket and mechanism for peptidomimetic agonism.

Proceedings of the National Academy of Sciences · May 13, 2022Peer-reviewedMolecular Biology

Constitutive signal bias mediated by the human GHRHR splice variant 1

Zhaotong Cong, Fulai Zhou, Chao Zhang, Xinyu Zou, Huibing Zhang, Yuzhe Wang, Qingtong Zhou, Xiaoqing Cai, Qiaofeng Liu, Jie Li, Lijun Shao, Chunyou Mao, Xi Wang, Jihong Wu, Tian Xia, , Ming‐Wei Wang

The paper identifies a splice variant of the GHRHR receptor that mediates constitutive signal bias towards β-arrestin recruitment, impacting downstream signaling pathways in prostate cancer cells.

Proceedings of the National Academy of Sciences · Oct 1, 2021Peer-reviewedMolecular Biology

Structural basis for the therapeutic advantage of dual and triple agonists at the human GIP, GLP-1 or GCG receptors

Fenghui Zhao, Qingtong Zhou, Zhaotong Cong, Kaini Hang, Xinyu Zou, Chao Zhang, Yan Chen, Antao Dai, Anyi Liang, Qianqian Ming, Mu Wang, Li-Nan Chen, Peiyu Xu, Rulue Chang, Wenbo Feng, , Ming‐Wei Wang

This study determines cryo-EM structures of dual and triple agonists bound to GIPR, GLP-1R, and GCGR to elucidate their superior efficacy over monoagonists in glucose homeostasis.

bioRxiv · Jul 29, 2021 · PreprintMolecular Biology

Molecular insights into ago-allosteric modulation of the human glucagon-like peptide-1 receptor

Zhaotong Cong, Li-Nan Chen, Honglei Ma, Qingtong Zhou, Xinyu Zou, Chenyu Ye, Antao Dai, Qing Liu, Wei Huang, Xianqiang Sun, Xi Wang, Peiyu Xu, Lihua Zhao, Tian Xia, Wenge Zhong, , Ming‐Wei Wang

The paper reports cryo-EM structures of GLP-1R with ago-allosteric modulators, revealing their mechanism of action and providing insights for therapeutic design.

Nature Communications · Jun 18, 2021Peer-reviewedMolecular Biology