Author

Kaini Hang

ShanghaiTech University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Molecular Biology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Approach:statistical model· 1

Frequent Co-Authors

Antao DaiiD· 3 shared Dehua YangiD· 3 shared Fenghui Zhao· 3 shared Ming‐Wei WangiD· 3 shared Qingtong ZhouiD· 3 shared Chao ZhangiD· 2 shared H. Eric XuiD· 2 shared Lihua ZhaoiD· 2 shared

Activity by Year

2021-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersMolecular Biology

Antao DaiORCID

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3 papers

Recent·Most cited

Ligand-independent modulation of GIPR signaling by splice variants

Kaini Hang, Lijun Shao, Qingtong Zhou, Fenghui Zhao, Antao Dai, Xiaoqing Cai, Raymond C. Stevens, Dehua Yang, Ming‐Wei Wang

The paper investigates how splice variants of GIPR modulate cAMP and β-arrestin signaling independently of ligand binding.

bioRxiv · Jan 24, 2022 · PreprintMolecular Biology

Structural basis for the therapeutic advantage of dual and triple agonists at the human GIP, GLP-1 or GCG receptors

Fenghui Zhao, Qingtong Zhou, Zhaotong Cong, Kaini Hang, Xinyu Zou, Chao Zhang, Yan Chen, Antao Dai, Anyi Liang, Qianqian Ming, Mu Wang, Li-Nan Chen, Peiyu Xu, Rulue Chang, Wenbo Feng, , Ming‐Wei Wang

This study determines cryo-EM structures of dual and triple agonists bound to GIPR, GLP-1R, and GCGR to elucidate their superior efficacy over monoagonists in glucose homeostasis.

bioRxiv · Jul 29, 2021 · PreprintMolecular Biology

Structural insights into hormone recognition by the human glucose-dependent insulinotropic polypeptide receptor

Fenghui Zhao, Chao Zhang, Qingtong Zhou, Kaini Hang, Xinyu Zou, Yan Chen, Fan Wu, Qidi Rao, Antao Dai, Wanchao Yin, Dandan Shen, Yan Zhang, Tian Xia, Raymond C. Stevens, H. Eric Xu, , Ming‐Wei Wang

The paper reports the cryo-EM structure of the human GIPR complexed with GIP and a Gs heterotrimer, revealing how GIP is recognized and activates the receptor.

eLife · Jul 13, 2021Peer-reviewedMolecular Biology