Author

Fenghui Zhao

Chinese Academy of Sciences

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Molecular Biology· 5

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 5 Organism:human· 5 Assay:protein structure· 2 Research Focus:protein structure prediction· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Approach:statistical model· 1

Frequent Co-Authors

Dehua YangiD· 5 shared Ming‐Wei WangiD· 5 shared Qingtong ZhouiD· 5 shared Antao DaiiD· 4 shared H. Eric XuiD· 4 shared Kaini Hang· 3 shared Lihua ZhaoiD· 3 shared Yan ZhangiD· 3 shared

Activity by Year

2021-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

5 shared papersMolecular Biology

Dehua YangORCID

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

A unique peptide recognition mechanism by the human relaxin family peptide receptor 4 (RXFP4)

Yan Chen, Qingtong Zhou, Jiang Wang, Youwei Xu, Yun Wang, Jiahui Yan, Yibing Wang, Qi Zhu, Fenghui Zhao, Chenghao Li, Chuan-Wei Chen, Xiaoqing Cai, Ross A. D. Bathgate, Chun Shen, H. Eric Xu, , Ming‐Wei Wang

The paper reports cryo-EM structures of RXFP4-Gi complexes with INSL5 and agonists, revealing a unique peptide-binding mechanism and subtype selectivity determinants.

bioRxiv · Jul 28, 2022 · PreprintMolecular Biology

A distinctive ligand recognition mechanism by the human vasoactive intestinal polypeptide receptor 2

Yingna Xu, Wenbo Feng, Qingtong Zhou, Anyi Liang, Jie Li, Antao Dai, Fenghui Zhao, Jiahui Yan, Chuan-Wei Chen, Hao Li, Lihua Zhao, Tian Xia, Yan Zhang, H. Eric Xu, Dehua Yang, Ming‐Wei Wang

This study reports the cryo-EM structure of the human VIP2R bound to PACAP27 and Gs, revealing a unique N-terminal helix conformation that stabilizes the ligand-receptor interface.

Nature Communications · Apr 27, 2022Peer-reviewedMolecular Biology

Ligand-independent modulation of GIPR signaling by splice variants

Kaini Hang, Lijun Shao, Qingtong Zhou, Fenghui Zhao, Antao Dai, Xiaoqing Cai, Raymond C. Stevens, Dehua Yang, Ming‐Wei Wang

The paper investigates how splice variants of GIPR modulate cAMP and β-arrestin signaling independently of ligand binding.

bioRxiv · Jan 24, 2022 · PreprintMolecular Biology

Structural basis for the therapeutic advantage of dual and triple agonists at the human GIP, GLP-1 or GCG receptors

Fenghui Zhao, Qingtong Zhou, Zhaotong Cong, Kaini Hang, Xinyu Zou, Chao Zhang, Yan Chen, Antao Dai, Anyi Liang, Qianqian Ming, Mu Wang, Li-Nan Chen, Peiyu Xu, Rulue Chang, Wenbo Feng, , Ming‐Wei Wang

This study determines cryo-EM structures of dual and triple agonists bound to GIPR, GLP-1R, and GCGR to elucidate their superior efficacy over monoagonists in glucose homeostasis.

bioRxiv · Jul 29, 2021 · PreprintMolecular Biology

Structural insights into hormone recognition by the human glucose-dependent insulinotropic polypeptide receptor

Fenghui Zhao, Chao Zhang, Qingtong Zhou, Kaini Hang, Xinyu Zou, Yan Chen, Fan Wu, Qidi Rao, Antao Dai, Wanchao Yin, Dandan Shen, Yan Zhang, Tian Xia, Raymond C. Stevens, H. Eric Xu, , Ming‐Wei Wang

The paper reports the cryo-EM structure of the human GIPR complexed with GIP and a Gs heterotrimer, revealing how GIP is recognized and activates the receptor.

eLife · Jul 13, 2021Peer-reviewedMolecular Biology