Author

Anyi Liang

Huazhong University of Science and TechnologyPrimary ORCID profile (0000-0003-3675-2709 · 1 paper)Unclaimed ORCID profile · follow to get notified of new preprints

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Anyi LiangiD1 paper · Chinese Academy of Medical Sciences & Peking Union Medical College

Biology Disciplines

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Molecular Biology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:protein structure prediction· 2 Assay:protein structure· 1

Frequent Co-Authors

Antao DaiiD· 3 shared Dehua YangiD· 3 shared Ming‐Wei WangiD· 3 shared Qingtong ZhouiD· 3 shared Yan ZhangiD· 3 shared Fenghui Zhao· 2 shared H. Eric XuiD· 2 shared Li-Nan Chen· 2 shared

Activity by Year

2021-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersMolecular Biology

Antao DaiORCID

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3 papers

Recent·Most cited

Structural basis of peptidomimetic agonism revealed by small molecule GLP-1R agonists Boc5 and WB4-24

Zhaotong Cong, Qingtong Zhou, Yang Li, Li-Nan Chen, Zi-Chen Zhang, Anyi Liang, Qing Liu, Xiaoyan Wu, Antao Dai, Tian Xia, Wei Wu, Yan Zhang, Dehua Yang, Ming‐Wei Wang

This paper reports cryo-EM structures of small molecule GLP-1R agonists Boc5 and WB4-24, revealing a novel binding pocket and mechanism for peptidomimetic agonism.

Proceedings of the National Academy of Sciences · May 13, 2022Peer-reviewedMolecular Biology

A distinctive ligand recognition mechanism by the human vasoactive intestinal polypeptide receptor 2

Yingna Xu, Wenbo Feng, Qingtong Zhou, Anyi Liang, Jie Li, Antao Dai, Fenghui Zhao, Jiahui Yan, Chuan-Wei Chen, Hao Li, Lihua Zhao, Tian Xia, Yan Zhang, H. Eric Xu, Dehua Yang, Ming‐Wei Wang

This study reports the cryo-EM structure of the human VIP2R bound to PACAP27 and Gs, revealing a unique N-terminal helix conformation that stabilizes the ligand-receptor interface.

Nature Communications · Apr 27, 2022Peer-reviewedMolecular Biology

Structural basis for the therapeutic advantage of dual and triple agonists at the human GIP, GLP-1 or GCG receptors

Fenghui Zhao, Qingtong Zhou, Zhaotong Cong, Kaini Hang, Xinyu Zou, Chao Zhang, Yan Chen, Antao Dai, Anyi Liang, Qianqian Ming, Mu Wang, Li-Nan Chen, Peiyu Xu, Rulue Chang, Wenbo Feng, , Ming‐Wei Wang

This study determines cryo-EM structures of dual and triple agonists bound to GIPR, GLP-1R, and GCGR to elucidate their superior efficacy over monoagonists in glucose homeostasis.

bioRxiv · Jul 29, 2021 · PreprintMolecular Biology