Brad A. Sutherland

Peptidylglycine α-amidating monooxygenase restores brain microvascular blood flow and improves recovery following ischemic stroke

This study shows that administering PAM improves capillary blood flow and reduces infarct volume in rats after ischemic stroke, leading to better neurological recovery.

Pericyte ablation causes hypoactivity and reactive gliosis in adult mice

This study shows that pericyte ablation in adult mice leads to blood-brain barrier leakage, gliosis, and behavioral changes such as reduced movement and impaired balance.

Rapamycin Treatment Reduces Brain Pericyte Constriction in Ischemic Stroke

This study shows rapamycin reduces brain pericyte contraction during ischemia but not viability, improving capillary diameter and openness after stroke.

Microglia contact cerebral vasculature through gaps between astrocyte endfeet

The paper investigates microglial interactions with cerebral vasculature using electron microscopy data, finding that 20% of microglia form direct contacts through gaps between astrocyte endfeet.

Microglia associations with brain pericytes and the vasculature are reduced in Alzheimer's disease

The paper identifies a subpopulation of microglia associated with pericytes in the brain and shows this population is reduced in Alzheimer's disease in the superior frontal gyrus.

An automated approach to improve the speed and accuracy of pericyte and microglia quantification in whole mouse brain sections

The paper presents an automated method using QuPath to quantify microglia and pericytes in whole mouse brain sections, showing regional differences in cell proportions.