Diffusible fraction of niche BMP ligand safeguards stem-cell differentiation
Sharif M. Ridwan, Autumn Twillie, Samaneh Poursaeid, Emma Kristine Beard, Muhammed Burak Bener, Matthew Antel, Ann E. Cowan, Shinya Matsuda, Mayu Inaba
The paper shows that BMP ligand diffuses from the niche and has opposing roles in maintaining stem cells and promoting differentiation of their daughter cells.
Nature Communications · Feb 7, 2024Peer-reviewedDevelopmental Biology