Shinya Matsuda

Shaping and interpretation of Dpp morphogen gradient by endocytic trafficking

The paper investigates how endocytic trafficking shapes and interprets the Dpp morphogen gradient in Drosophila, showing that Dynamin-mediated internalization shapes the gradient while MVB formation affects its interpretation.

Diffusible fraction of niche BMP ligand safeguards stem-cell differentiation

The paper shows that BMP ligand diffuses from the niche and has opposing roles in maintaining stem cells and promoting differentiation of their daughter cells.

Heterodimerization-dependent secretion of BMPs in Drosophila

The paper investigates the formation and function of BMP heterodimers in Drosophila, showing they are essential for signaling and wing development.

Dally is not essential for Dpp spreading or internalization but for Dpp stability by antagonizing Tkv-mediated Dpp internalization

The paper investigates the role of Dally in Dpp morphogen gradient formation and signaling, finding that Dally stabilizes Dpp by antagonizing receptor-mediated internalization, rather than through direct interaction with Dpp.

Asymmetric requirement of Dpp/BMP morphogen dispersal in the Drosophila wing disc

The paper shows that Dpp/BMP morphogen dispersal is not strictly required for overall wing patterning and growth in Drosophila, challenging a long-standing dogma.