David Alcantara‐Gonzalez

The paper modifies single-nucleus RNA sequencing protocols to study gene expression in small brain circuits, focusing on the dentate gyrus in a mouse Alzheimer's disease model.

The paper investigates early hyperexcitability in mossy cells of the dentate gyrus in the Tg2576 Alzheimer's model, finding increased excitatory events and intrinsic changes before memory deficits occur.

This study shows that high choline diets in early life improve cognitive and neuronal outcomes in a mouse model of Alzheimer's, while low choline diets have mixed adverse effects.

The paper finds that dorsal and ventral mossy cells in the mouse hippocampus differ in their long-range axonal projections, with dorsal axons terminating in multiple layers while ventral axons remain restricted to the inner molecular layer.

This study examines electrophysiological changes in dentate gyrus granule cells of Tg2576 mice, showing increased excitation, reduced inhibition, and altered cholinergic regulation.