Paige Leary

Transcriptional profiling of extraocular motor neurons reveals sim1a as a candidate strabismus-related gene

The paper identifies sim1a as a candidate gene for strabismus using transcriptomic analysis and CRISPR/Cas9 mutagenesis in zebrafish.

Sensation is Dispensable for the Maturation of the Vestibulo-ocular Reflex

The paper shows that sensory experience is not required for the maturation of the vestibulo-ocular reflex in larval zebrafish, as neuromuscular junction development drives reflex maturation.

Tau load in select brainstem neurons predicts the severity and nature of balance deficits in the absence of cell death

The paper shows that tau load in specific brainstem neurons predicts balance deficits before cell death in zebrafish.

Choline supplementation in early life improves and low levels of choline can impair outcomes in a mouse model of Alzheimer's disease.

This study shows that high choline diets in early life improve cognitive and neuronal outcomes in a mouse model of Alzheimer's, while low choline diets have mixed adverse effects.

Motor neurons are dispensable for the assembly of a sensorimotor circuit for gaze stabilization

The paper shows motor neurons are not required for proper connectivity in the vestibular reflex circuit for gaze stabilization.

Enhanced excitability of the hippocampal CA2 region and its contribution to seizure generation in a mouse model of temporal lobe epilepsy

This study investigates the role of hippocampal CA2 region in seizure generation in a mouse model of temporal lobe epilepsy, finding that enhanced excitability and reduced inhibition in CA2 contribute to seizure activity.