Justin J. Botterill

The paper investigates early hyperexcitability in mossy cells of the dentate gyrus in the Tg2576 Alzheimer's model, finding increased excitatory events and intrinsic changes before memory deficits occur.

The paper describes a method to selectively activate mossy cells (MCs) in hippocampal slices using optogenetics and shows that MC input to granule cells (GCs) is weak but widespread.

This study shows that increasing adult-born neurons in mice reduces chronic seizures and neuronal loss after status epilepticus, with a notable sex difference.

This study shows that high choline diets in early life improve cognitive and neuronal outcomes in a mouse model of Alzheimer's, while low choline diets have mixed adverse effects.

This study shows that activating the dorsal peduncular cortex (DP/DTT) in mice increases anxiety-like behavior and affects fear extinction, suggesting a role in emotional regulation.

The paper investigates off-target expression of Cre-dependent AAVs in wild-type mice and finds extensive Cre-independent viral expression despite vendor, serotype, and promoter variations.

The paper finds that dorsal and ventral mossy cells in the mouse hippocampus differ in their long-range axonal projections, with dorsal axons terminating in multiple layers while ventral axons remain restricted to the inner molecular layer.

This study shows that mossy cells in the dentate gyrus bidirectionally regulate cognitive and anxiety-like behaviors in mice, with sex-specific effects.