Helen E. Scharfman

The paper investigates BDNF expression and estrogen receptor presence in mossy cells of the dentate gyrus, finding estrous cycle-dependent BDNF levels and high ER expression in MCs.

The paper modifies single-nucleus RNA sequencing protocols to study gene expression in small brain circuits, focusing on the dentate gyrus in a mouse Alzheimer's disease model.

This paper shows that chemogenetic activation of hippocampal CA2 neurons increases seizure frequency and duration in a mouse model of epilepsy.

The paper investigates early hyperexcitability in mossy cells of the dentate gyrus in the Tg2576 Alzheimer's model, finding increased excitatory events and intrinsic changes before memory deficits occur.

The paper describes a method to selectively activate mossy cells (MCs) in hippocampal slices using optogenetics and shows that MC input to granule cells (GCs) is weak but widespread.

This study shows that increasing adult-born neurons in mice reduces chronic seizures and neuronal loss after status epilepticus, with a notable sex difference.

This study shows that high choline diets in early life improve cognitive and neuronal outcomes in a mouse model of Alzheimer's, while low choline diets have mixed adverse effects.

The paper compares interictal spikes (IIS) and high frequency oscillations (HFOs>250Hz) in preclinical Alzheimer's disease models, finding HFOs more frequent and occurring across more behavioral states.

This study identifies the dentate gyrus as the dominant site of interictal spikes in Alzheimer's disease models and shows that cholinergic control from the medial septum modulates these spikes during REM sleep.

The paper investigates inhibitory deficits in the hippocampal CA2 region of a mouse model of temporal lobe epilepsy, identifying reduced cholecystokinin-expressing interneurons and impaired inhibition.

The paper examines mossy fiber BDNF protein stability in AD mouse models and finds it remains unchanged with age, correlating with neuronal activity and resistance to amyloid-beta accumulation.

This study shows high frequency oscillations (HFOs) occur in Alzheimer's disease mouse models and are not unique to epilepsy.

This study investigates how CBD modulates LPI-GPR55 signaling at excitatory and inhibitory synapses, showing its role in reducing seizure activity by blocking LPI's pro-excitatory effects and enhancing inhibitory synaptic strength.

This study investigates the role of hippocampal CA2 region in seizure generation in a mouse model of temporal lobe epilepsy, finding that enhanced excitability and reduced inhibition in CA2 contribute to seizure activity.

This paper demonstrates that a modified intrahippocampal kainic acid model in mice produces robust, frequent convulsive seizures with human-like onset patterns and high frequency oscillations.

This paper develops an in vitro method to record and image spreading depolarizations and seizure-like events in mouse hippocampal slices without focal stimulation.

The paper investigates off-target expression of Cre-dependent AAVs in wild-type mice and finds extensive Cre-independent viral expression despite vendor, serotype, and promoter variations.

The paper finds that dorsal and ventral mossy cells in the mouse hippocampus differ in their long-range axonal projections, with dorsal axons terminating in multiple layers while ventral axons remain restricted to the inner molecular layer.

This study shows that mossy cells in the dentate gyrus bidirectionally regulate cognitive and anxiety-like behaviors in mice, with sex-specific effects.

This study examines electrophysiological changes in dentate gyrus granule cells of Tg2576 mice, showing increased excitation, reduced inhibition, and altered cholinergic regulation.