Chemogenetic activation of hippocampal area CA2 promotes acute and chronic seizures in a mouse model of epilepsy
John J. LaFrancois, Meghan Kennedy, Monarchsinh Rathod, Bina Santoro, Christos Panagiotis Lisgaras, Steven A. Siegelbaum, Helen E. Scharfman
This paper shows that chemogenetic activation of hippocampal CA2 neurons increases seizure frequency and duration in a mouse model of epilepsy.
Neurobiology of Disease · Jan 3, 2026Peer-reviewedNeuroscience