Luis G Paz-Ares

This study identifies MDM2 stabilization of NICD in response to platinum chemotherapy in NSCLC, showing that targeting MDM2 and NICD improves survival and reduces tumor growth.

This paper develops a framework to predict future oncogene amplification or tumour suppressor deletion in cancer using genomic data, achieving an average AUC of 0.87.

This study identifies FMO4 as a driver of lung adenocarcinoma by stabilizing the MAT2A/MAT2B complex and inhibiting ferroptosis.

This study shows that engineered CD4+ TIL secreting TCE can induce tumor regression in NSCLC PDX models by redirecting non-tumor dominant T cell clones.