Ángel Fernández-Sanromán

Distinct functions of PBRM1 and BAP1 reconcile the course of kidney cancer evolution and disease progression

This study identifies distinct molecular programs in PBRM1- and BAP1-driven ccRCC, explaining their different evolutionary trajectories and clinical outcomes.

Tracking ongoing chromosomal instability using single-cell whole-genome sequencing

This paper develops a computational framework using single-cell whole-genome sequencing to identify ongoing chromosomal instability, showing its utility in cancer models and clinical samples.

A comprehensive genetic catalog of human double-strand break repair

This study presents a comprehensive catalog of human double-strand break repair genes using genome-wide knockout data, revealing novel mechanisms and factors involved in DSB repair.

Forecasting oncogene amplification and tumour suppressor deletion

This paper develops a framework to predict future oncogene amplification or tumour suppressor deletion in cancer using genomic data, achieving an average AUC of 0.87.