Author

Sara Bernardo

InsermORCID 0000-0002-2974-5327Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 2 Research Focus:drug response / drug discovery· 2 Organism:human· 2 Research Focus:cell type annotation· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Approach:genetic perturbation / CRISPR· 1 Assay:proteomics· 1

Frequent Co-Authors

Adrian Vega· 1 shared Aidan C.A. TomlinsoniD· 1 shared Alba SantosiD· 1 shared Alexandre DjianeiD· 1 shared Alyna KattiiD· 1 shared Amina-Milissa Maacha· 1 shared Anais Giry· 1 shared Andrea PasquieriD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperCancer Biology

Adrian Vega

Mutual co-authors in cluster

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2 papers

Recent·Most cited

MDM2 stabilization of Notch intracellular domain upon DNA damage plays a major role in non-small cell lung carcinoma response to platinum chemotherapy

Sara Bernardo, Lisa J. Brunet, Quentin Dominique Thomas, David Bracquemond, Céline Bouclier, Marie Colomb, Maicol Mancini, Eric Fabbrizio, Alba Santos, Sylvia Fenosoa Rasamizafy, Amina-Milissa Maacha, Anais Giry, Emilie Bousquet, Laura Papon, Marion Goussard, , Antonio Maraver

This study identifies MDM2 stabilization of NICD in response to platinum chemotherapy in NSCLC, showing that targeting MDM2 and NICD improves survival and reduces tumor growth.

EMBO Molecular Medicine · Jan 16, 2026Peer-reviewedCancer Biology

Genetic mechanisms of resistance to targeted KRAS inhibition

Bianca Jay Diaz, M.S. Kops, Sara Bernardo, Henri Schmidt, Elizabeth Grankowsky, Adrian Vega, Chen Zhang, Matthew Joseph Bott, Maria Skamagki, Aidan C.A. Tomlinson, Nicole A. Vita, Alyna Katti, Mark P. Labrecque, Ida Aronchik, Mallika Singh, Lukas E. Dow

This study identifies genetic mechanisms of resistance to KRAS inhibitors by using CRISPR screens to find resistance mutations and signaling rewiring in NSCLC.

bioRxiv · Aug 4, 2025 · PreprintCancer Biology