ImmunologyCell ReportsPeer-reviewed
Activation of the endoplasmic reticulum stress regulator IRE1α compromises pulmonary host defenses
Amit Sharma, Linda M. Heffernan, Ky V. Hoang…·Basel H. Abuaita
This study shows that activating IRE1α in the lungs during MRSA infection worsens pneumonia by increasing inflammation and cell death, but blocking IRE1α improves survival and reduces lung damage.
12 citations